5-Amino-1MQ（10 VIALS / BOX）

Technical Overview

5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme predominantly expressed in adipose tissue and liver. By blocking NNMT’s activity, researchers can investigate how this enzyme regulates NAD+ availability—a critical cofactor involved in hundreds of cellular reactions. Scientists became interested when studies showed that NNMT inhibition could influence fat metabolism, muscle regeneration, and even cellular aging pathways, revealing NNMT as a central metabolic regulator.

Unlike compounds that target a single receptor or hormone, 5-Amino-1MQ works upstream by inhibiting the NNMT enzyme—a strategic intervention that simultaneously influences multiple pathways including NAD+ metabolism, mitochondrial function, and fat cell biology. This makes it uniquely valuable for studying the interconnected nature of metabolic regulation, aging processes, and cellular energy balance across different tissue types.

Specifications

Purity: ≥ 99% (Mass Spectrometry Verified)
Appearance: Lyophilized Solid
Format: Research Compound
Reconstitution: Recommended for laboratory titration using bacteriostatic water.

How It Works (What Makes It Interesting)

Research suggests 5-Amino-1MQ influences cellular metabolism through several interconnected mechanisms:

• NNMT Inhibition – Blocks the enzyme that converts nicotinamide to 1-methylnicotinamide, preserving nicotinamide for NAD+ synthesis
• NAD+ Elevation – Increases cellular NAD+ levels by preventing its depletion, enhancing energy metabolism and activating NAD+-dependent pathways
• SIRT1 Activation – Elevated NAD+ activates sirtuin-1 (SIRT1), often called the “longevity gene,” which influences DNA repair, inflammation, and stress resistance
• Adipocyte Modulation – Reduces fat cell size and promotes lipolysis (fat breakdown) in white adipose tissue without affecting food intake
• Mitochondrial Enhancement – Improves mitochondrial function and cellular energy production through NAD+-dependent processes
• Muscle Stem Cell Activation – Enhances muscle stem cell (muSC) activity and myoblast differentiation, particularly relevant in aging muscle models

Common Research Applications

Obesity & Fat Metabolism Models: Diet-induced obesity (DIO) studies, adipocyte size reduction research, white adipose tissue metabolism, lipolysis mechanisms, body composition analysis

Metabolic Disorder Research: Type 2 diabetes models, insulin resistance studies, glucose tolerance testing, lipid profile analysis, metabolic syndrome investigations

Aging & Longevity Studies: Cellular senescence models, NAD+ depletion research, SIRT1 pathway analysis, mitochondrial dysfunction, epigenetic aging markers

Muscle Regeneration Research: Sarcopenia models, age-related muscle loss, muscular dystrophy studies (including DMD), muscle stem cell function, post-injury recovery analysis

Neurodegenerative Models: Parkinson’s disease research, cognitive function studies, synaptic transmission analysis, NAD+ depletion in neural tissue, neuromuscular junction function

Cancer Metabolism Studies: NNMT overexpression in tumors, metabolic reprogramming research, kidney cancer models, ovarian cancer investigations

Notice

American Peptides provides this compound as a reference material for scientific inquiry. All applications must be conducted by qualified professionals in controlled laboratory environments.